Applications of (4+3) Cycloaddition Strategies to the Synthesis of Natural Products
Abstract: (4+3) Cycloadditions and its variants have been widely applied in synthesis. In this review article, we summarize some of more recent applications of (4+3) cycloadditions, including formal (4+3) cycloadditions, in the synthesis of natural products. Many of these natural product targets have cycloheptanoid frameworks for which the (4+3) cycloaddition is a convergent strategy for their assembly. Some natural product targets do not possess seven membered rings, and their syntheses have exploited the functional group endowed (4+3) cycloadducts resulting from these reactions, highlighting the utility of this methodology for the synthesis of many kinds of complex molecules.