News Archive

January 17, 2019

Congratulations to Fan and Jerome for their new review paper in Synthesis Golden Anniversary Issue!

Pyrroles as Dienes in (4+3) Cycloadditions

 

Abstract: This Short Review summarizes the examples to date of successful (4+3) cycloadditions, including formal (4+3) cycloadditions, where pyrrole derivatives reacted as the diene component, to provide aza-bridged bicyclic and polycyclic adducts. 

December 31, 2018

Prof. P. Chiu is Associate Editor of Organic Letters

Since 2019, Prof. Chiu became one of the new Associate Editors of the ACS journal, Organic Letters, which has an impact factor of 6.555 in 2018.

Welcome to our postdoc, Dr. Stephan Scheeff!

Stephan completed his Ph.D. in 2018 at the University of Bonn, Germany, with Prof. Dirk Menche.  Welcome!

October 16, 2018

Welcome Kevin Kong, Laidlaw Scholar!

Kevin is from HKU and he earned a Laidlaw Scholarship to conduct research at the University of Leeds and at HKU.  Welcome!

November 07, 2018

Congratulations to Zengsheng and Yun for their new review paper in Chem. Soc. Rev.!

Applications of (4+3) Cycloaddition Strategies to the Synthesis of Natural Products 

 

Abstract: (4+3) Cycloadditions and its variants have been widely applied in synthesis.  In this review article, we summarize some of more recent applications of (4+3) cycloadditions, including formal (4+3) cycloadditions, in the synthesis of natural products.  Many of these natural product targets have cycloheptanoid frameworks for which the (4+3) cycloaddition is a convergent strategy for their assembly.  Some natural product targets do not possess seven membered rings, and their syntheses have exploited the functional group endowed (4+3) cycloadducts resulting from these reactions, highlighting the utility of this methodology for the synthesis of many kinds of complex molecules.

October 01, 2018

Congratulations to Ignatius Ip and Yufen Zheng for the Best TA awards in 2018!

Ignatius has been the Tutor for CHEM2441.  Yufen has been demonstrating CHEM4443.

September 02, 2018

Welcome Fan Hu and Yongjie Shi as the newest members to join the PC group!

September 02, 2018

Welcome Tommy Kwan and Ken Cheung as FYP students in the PC group!

August 14, 2018

Welcome summer student, Mariam Yusuf, Laidlaw Scholar!

Mariam is a Laidlaw Scholar from University College London UK.  The Laidlaw Scholar program is a special exchange between UCL and HKU.  Mariam's major is in medicinal chemistry.  She will be working with the PC group August 7-September 13.  Welcome!

July 10, 2018

Welcome summer students: Ken Cheung, Alvin Chu, Tommy Kwan, Vincent Lau, Nicholas Yeung!

Our summer students from HKU will be in the lab July 11- August 30.  Welcome!

May 20, 2018

Welcome Aishanee Sur to the PC group as a Summer Intern!

Aishanee is an IIT Bombay MSc student and will intern in our group from May 21-July 14.  Welcome! 

May 09, 2018

Congratulations to Karen for her new paper in Angew. Chem. Int. Ed.!

Intramolecular (4+3) Cycloadditions of Pyrroles and Application to the Synthesis of the Core of Class II Galbulimima Alkaloids

 

Abstract: The first intramolecular (4+3) cycloadditions with pyrroles to generate optically-enriched cycloadducts having the nortropane substructure occurred in good yields with epoxy enolsilanes as electrophiles. Using this pyrrole cycloaddition as the key step, we have achieved the asymmetric synthesis of the BCDEF rings common to the Class II galbulimima alkaloids.

March 19, 2018

Congratulations to Elvis for his new paper in the Journal of the American Chemical Society!

Synthesis and Applications of Unquaternized C-bound Boron Enolates

 

Abstract: A general and facile method to prepare unquaternized C-bound boron enolates by a ligand-controlled O-to-C isomerization is reported. Using this protocol, C-bound pinacolboron enolates have been isolated in pure form for the first time, and have been fully characterized by NMR spectroscopy and X-ray crystallography. In contrast to the general perception, such C-boron enolates are stable without coordinative saturation at the boron.  Moreover, C-boron enolates present reactivities that are distinct from the O-boron enolates, and their applications in C‒O and C‒C bond formations are demonstrated.

January 03, 2018

Congratulations to Yu Chen and Diana Chan for their new paper in Chemistry-A European Journal!

Transannular [4+3] Cycloadditions of Macrocyclic Epoxy Ketones

 

 

ABSTRACT: Transannular [4+3] cycloadditions of dienophiles derived from macrocyclic epoxy ketones produce fused ring systems having central cycloheptane subunits.  In some cases, base directly induced cycloisomerization of the epoxy ketones to yield the cycloadducts; in others, the epoxy ketones were transformed into their corresponding enolsilanes before undergoing cycloaddition.  Enantiomerically-enriched tricyclic arrays are obtained from cycloadditions starting from optically pure epoxy ketones.

 

October 15, 2017

Diana will be working with Dr. Mike Porter at UCL in London, UK.

August 13, 2017

Welcome Yun He to the PC group!

Yun is originally from Chengdu China.  He studied his BSc in chemistry at the USTC, Hefei, China

August 10, 2017

Congratulations to Ignatius Ip, Emily Lam and Dr. Zhengning Li for their new paper in Org. Lett!

Rearrangements of alpha-diazo-beta-hydroxyketones for the synthesis of bicyclo[m.n.1]alkanones

ABSTRACT: Rhodium-catalyzed decomposition of fused bicyclic a-diazo-b-hydroxyketones results in good yields of bridged bicyclo[m.n.1]ketones via a rearrangement pathway.

August 09, 2017

Congratulations to Ignatius Ip and Siyuan Guo for the Best TA awards in 2017!

Ignatius has been the Tutor for CHEM2441.  Siyuan has been demonstrating CHEM3443.

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Department of Chemistry

Faculty of Science

The University of Hong Kong

© 2020 by Pauline Chiu